CHRONIC MYELOGENOUS LEUKEMIA (CML) IN THE ELDERLY
نویسندگان
چکیده
منابع مشابه
Chronic Myelogenous Leukemia (CML) in the elderly
Published: June 1, 2014 Received: May 5, 2014 Accepted: May 6, 2014 Citation: Mediterr J Hematol Infect Dis 2014, 6(1): e2014037, DOI: 10.4084/MJHID.2014.037 This article is available from: http://www.mjhid.org/article/view/13434 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unre...
متن کاملChronic myelogenous leukaemia (CML)
Evidence exists for the involvement of the most primitive and quiescent hematopoietic stem cell compartiment (CD34+/CD38-, Thy1+): t(9;22) is found in myeloid progenitor and in B-lymphocytes progenitors, but, involvement of the T-cell lineage is extremely rare. The existence of a highly quiescent stem cell population has been demonstrated in patients with CML. More recently, the presence of Ph ...
متن کاملChronic myelogenous leukaemia (CML)
Clinics Splenomegaly; chronic phase (lasts about 3 yrs) with maintained cell’s normal activities, followed by accelerated phase(s)(blasts still < 15%), and blast crisis (BC-CML) with blast cells > 30%; blood data: WBC: 100 X 10/l and more during chronic phase, with basophilia; a few blasts; thrombocytosis may be present; low leucocyte alkaline phosphatases; typical acute leukaemia (AL) blood da...
متن کاملChronic myelogenous leukemia (CML): resistance to tyrosine kinase inhibitors.
Chronic myelogenous leukemia (CML) is attributed to the chromosomal translocation t(9;22)(q34;q11), yielding the Philadelphia (Ph) chromosome. This translocation generates a fusion gene that encodes BCR-ABL, a constitutively active protein tyrosine kinase. Signal transduction pathways stimulated by BCR-ABL kinase activity promote cell survival and proliferation while inhibiting apoptosis [1]. T...
متن کاملGraft-versus-leukemia (GVL) against mouse blast-crisis chronic myelogenous leukemia (BC-CML) and chronic-phase chronic myelogenous leukemia (CP-CML): shared mechanisms of T cell killing, but programmed death ligands render CP-CML and not BC-CML GVL resistant.
Graft-versus-leukemia (GVL) against chronic-phase chronic myelogenous leukemia (CP-CML) is potent, but it is less efficacious against acute leukemias and blast-crisis chronic myelogenous leukemia (BC-CML). The mechanisms underlying GVL resistance are unknown. Previously, we found that alloreactive T cell targeting of GVL-sensitive bcr-abl-induced mouse CP-CML (mCP-CML) required TCR-MHC interact...
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ژورنال
عنوان ژورنال: Mediterranean Journal of Hematology and Infectious Diseases
سال: 2014
ISSN: 2035-3006
DOI: 10.4084/mjhid.2014.037